Fig. 8: TILs, TP53 mutations and copy number alterations. | Nature Communications

Fig. 8: TILs, TP53 mutations and copy number alterations.

From: Molecular profiling of aromatase inhibitor sensitive and resistant ER+HER2- postmenopausal breast cancers

Fig. 8: TILs, TP53 mutations and copy number alterations.The alternative text for this image may have been generated using AI.

a Violin/Boxplot of TILs associated with TP53 status in GRs, PRs ESR1HIGH and PRs ESR1LOW. Boxplots present 25th, 50th (median), and 75th percentile values. Whiskers extend no larger than ±1.5 times the inter-quartile range with outliers plotted individually beyond this range. The number of independent samples used for comparisons between GRs and PRs is shown. Significant differences (p < 0.05) determined by two-sided Mann–Whitney tests. b Barplot of the percent of tumours with TP53 mutations for LumA, LumB and HER2-E subtypes in GRs, PRs ESR1HIGH. c Plots of the percent of GRs (blue) or PRs ESR1HIGH (orchid) with gains or losses at individual chromosomal locations. Purple bars highlight regions with significant differences between GRs and PRs ESR1HIGH (Fisher-exact test with FDR/Benjamini and Hochberg adjustment). d Percent of patients with TP53 mutations and/or loss of copy number. Source data are provided as a Source data file.

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