Fig. 1: Cryo-EM structure of HCV sE1E2.SZ ectodomain in complex with antibodies.
From: Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies
a Schematic representation of sE1E2.SZ heterodimer ectodomain. Respective leucine zipper SYNZIP (SZ) scaffolds, SZ1 and SZ2, are labeled along with disulfide bonds, N-linked glycans, and the furin cleavage site. b Overall cryo-EM structure of sE1E2.SZ (E1, blue; E2, orange) bound by antibodies AR4A (heavy chain, purple; light chain, pink) and HEPC74 (heavy chain, green; light chain, light green). HC heavy chain, LC light chain. c 3.65 Å cryo-EM map used for structure determination. d Structure of E2 (orange) shown against a surface representation of E1 (blue). e Structure of E1 (blue) rotated by 180° relative to (d) and shown against a surface representation of E2 (orange). N-linked glycans are colored gray.
