Fig. 3: Structural features of E1.
From: Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies
a Schematic representation of E1 colored by subregion. Listed subregions include the N-terminal domain (NTD, residues 192–205), E1 core (residues 206–255 and 295–299), pFP-containing region (PCR, residues 256–298), C-terminal loop (CTL, residues 300–314), and stem (residues 315–351). Regions that were not resolved in the structure are depicted in gray. b E1 structure colored by subregion and shown against a semi-transparent surface representation of E2 (light gray), shown in 135° orientations. c Cryo-EM map density for E1 structure shown in same orientations as in (b). d Overlay of E1 structure (colored and oriented as in (b)) against an AlphaFold2-generated E1 model (raspberry). N-linked glycans and disulfide bonds are shown as gray and yellow sticks, respectively.
