Fig. 6: Glycan shield and antigenic targets.
From: Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies
a Surface representation of sE1E2.SZ with bound AR4A and HEPC74 variable regions (cartoon), shown in three orientations and colored as in Fig. 1 with N-linked glycans shown as cyan spheres. b Sequence entropy mapped onto the surface of sE1E2.SZ, scaled on a gradient from 0 (conserved, white) to 100 (variable, purple), shown in the same orientations as in (a). c Mapped footprints of antibodies AR4A (purple), HEPC74 (green), and collectively of antibodies that target the neutralizing face (gray), antigenic domain C (salmon), and antigenic domain A (pink), shown in same orientations as in (a) with N-linked glycans colored cyan. d Contribution of E2 N-linked glycan N695 (cyan) to the interface with antibody AR4A, with closeup view shown. e Contribution of E2 N-linked glycans N430 and N448 to the interface with HEPC74, with closeup view shown. HC heavy chain, LC light chain, AD antigenic domain. Source data are provided as a Source Data file.
