Table 3 Detailed statistics for Fig. 3
From: Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice
Statistical test | Factor | n | Statistic | 95% confidence interval | p value (adjusted where appropriate) | Corresponding figure | |
|---|---|---|---|---|---|---|---|
A | 6/group | Fig. 3e | |||||
Two-tailed unpaired t test | Netrin-1:Tubulin Fold Change | t(10) = 3.499 | −0.8213 to −0.1823 | 0.0057 | |||
B | 6/group | Fig. 3f | |||||
Two-tailed unpaired t test | Netrin-1:Tubulin Fold Change | t(10) = 0.8927 | −0.4246 to 0.1817 | 0.393 | |||
C | 6/group | Fig. 3h | |||||
Two-tailed unpaired t test | Netrin-1:Tubulin Fold Change | t(10) = 0.04532 | −0.5956 to 0.5719 | 0.9647 | |||
D | 6/group | Fig. 3i | |||||
Two-tailed unpaired t test | Netrin-1:Tubulin Fold Change | t(10) = 2.829 | 0.1585 to 1.333 | 0.0179 | |||
E | 6 | Fig. 3h | |||||
Pearson r | r = −0.8302, r2 = 0.6892 | −0.9809 to −0.05703 | 0.0408 | ||||
F | Scrambled + Saline = 5 Scrambled + AMPH = 5 Netrin-1 shRNA + Saline = 4 Netrin-1 shRNA + AMPH = 5 | Fig. 3i | |||||
Generalized Estimating Equations analysis (GEE) | Drug (between subjects) | Wald Chi-Square = 2.281 (df = 1) | 0.131 | ||||
Virus (between subjects) | Wald Chi-Square = 6.884(df = 1) | 0.009 | |||||
Region (within subjects) | Wald Chi-Square = 1546.853 (df = 2) | <0.001 | |||||
Drug × Virus | Wald Chi-Square = 0.589 (df = 1) | 0.443 | |||||
Virus × Region | Wald Chi-Square = 2.083 (df = 2) | 0.353 | |||||
Drug × Region | Wald Chi-Square = 5.341 (df = 2) | 0.69 | |||||
Drug × Virus × Region | Wald Chi-Square = 10.119 (df = 2) | 0.006 | |||||
Dunnett’s multiple comparisons test | Scrambled:Saline vs. Scrambled:Amphetamine within Cg1 | q(15) = 0.9696 | −28.73 to 13.19 | 0.6594 | |||
Dunnett’s multiple comparisons test | Scrambled:Saline vs. Netrin-1 shRNA:Saline within Cg1 | q(15) = 1.641 | −36.17 to 8.279 | 0.2763 | |||
Dunnett’s multiple comparisons test | Scrambled:Saline vs. Netrin-1 shRNA:Amphetamine within Cg1 | q(15) = 1.537 | −33.28 to 8.635 | 0.323 | |||
Dunnett’s multiple comparisons test | Scrambled:Saline vs. Scrambled:Amphetamine within PrL | q(15) = 0.518 | −34.05 to 22.79 | 0.9182 | |||
Dunnett’s multiple comparisons test | Scrambled:Saline vs. Netrin-1 shRNA:Saline within PrL | q(15) = 0.6796 | −37.98 to 22.31 | 0.8399 | |||
Dunnett’s multiple comparisons test | Scrambled:Saline vs. Netrin-1 shRNA:Amphetamine within PrL | q(15) = 2.746 | −58.27 to −1.426 | 0.0388 | |||
Dunnett’s multiple comparisons test | Scrambled:Saline vs. Scrambled:Amphetamine within IL | q(15) = 0.7311 | −9.019 to 16.02 | 0.8106 | |||
Dunnett’s multiple comparisons test | Scrambled:Saline vs. Netrin-1 shRNA:Saline within IL | q(15) = 0.5618 | −16.13 to 10.43 | 0.8993 | |||
Dunnett’s multiple comparisons test | Scrambled:Saline vs. Netrin-1 shRNA:Amphetamine within IL | q(15) = 2.676 | −25.33 to −0.2912 | 0.0445 |
