Table 1 Statistical comparisons of different features of the MLL cohort
From: Computational analysis of peripheral blood smears detects disease-associated cytomorphologies
Variable | Coefficient | Standard error/difference estimate | p-value | Model | Formula |
|---|---|---|---|---|---|
Age | 0.11 | 0.01 | 8 × 10−16 | Binomial regression | Has MDS ~ age + sex |
Sex (is male) | 1.20 | 0.32 | 2 × 10−4 | ||
Normal (vs. baseline) | 6750 | 556 | <2 × 10−16 | Linear regression | WBCC (/uL) ~ Condition |
MDS (vs. normal) | −1272 | 610 | 0.04 | ||
Anemia (vs. normal) | −1880 | 713 | 9 × 10−3 | ||
Normal (vs. baseline) | 14.29 | 0.30 | <2 × 10−16 | Linear regression | Hb (g/dL) ~ Condition |
MDS (vs. normal) | −4.35 | 0.32 | <2 × 10−16 | ||
Anemia (vs. normal) | −6.39 | 0.38 | <2 × 10−16 | ||
Normal (vs. baseline) | 256 × 103 | 23 × 103 | <2 × 10−16 | Linear regression | Plt (/uL) ~ Condition |
MDS (vs. normal) | −48 × 103 | 26 × 103 | 0.06 | ||
Anemia (vs. normal) | −40 × 103 | 30 × 103 | 0.2 | ||
Normal | 256 × 103 | [111 × 103,182 × 103] | 3 × 10−12 | Two-sided t-test | Plt (/uL) ~ Megaloblastic anemia vs. normal |
Megaloblastic anemia | 110 × 103 | ||||
SF3B1-mutant MDS | 282 × 103 | [131 × 103,200 × 103] | <2 × 10−16 | Two-sided t-test | Plt (/uL) ~ SF3B1-mutant MDS vs. other MDS |
Other MDS | 117 × 103 | ||||
SF3B1-mutant MDS | 282 × 103 | [−62 × 103,10 × 103] | 0.15 | Two-sided t-test | Plt (/uL) ~ SF3B1-mutant MDS vs. normal |
Normal | 256 × 103 | ||||
SF3B1-mutant MDS | 9.80 | [−0.83,0.22] | 0.25 | Two-sided t-test | Hb (g/dL) ~ SF3B1-mutant MDS vs. other MDS |
Other MDS | 10.10 | ||||
SF3B1-mutant MDS | 6253 | [655,2801] | 2 × 10−3 | Two-sided t-test | WBCC (/µL) ~ SF3B1-mutant MDS vs. other MDS |
Other MDS | 4525 | ||||
SF3B1-mutant MDS | 6253 | [−1515,522] | 0.3 | Two-sided t-test | WBCC (/µL) ~ SF3B1-mutant MDS vs. normal |
Normal | 6750 |
