Fig. 5: The putative mechanical-coupling mechanism of OSCA/TMEM63 channels.
From: A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity
a–c The putative force-activation model of monomeric TMEM63s or dimeric coupled OSCAs (a), the putative lyso-PC-modulation model of dimeric coupled OSCA channels (b) and the putative force-activation model of dimeric coupled OSCA channels (c) are shown as cartoons. The lipid plug is shown as a wheat cartoon. Force or high-osmolality shock causes deformation of the local membrane, which may induce a pulling force on the lipid plug to drive channel opening (a, c). The insertion of two putative lyso-PC molecules causes the extension of the central cavity, providing a pathway to channel activation (b).
