Fig. 8: Adipocyte H1.2 deficiency reduces weight gain through adaptive thermogenesis.
From: Linker histone variant H1.2 is a brake on white adipose tissue browning
a Experimental design. Normal chow (NC)-fed WT mice and H1.2AKO mice were housed at 30 °C from 4-week-old for 15 weeks. b–e Body weight (b), anatomy (c) and different tissue weights (d, f) of NC-fed WT and H1.2AKO mice housed at 30 °C (WT mice, n = 4; H1.2AKO mice, n = 6; unpaired two-tailed Student’s t test). f Representative H&E staining of eWAT/iWAT/BAT and average adipocyte area of eWAT and iWAT of WT and H1.2AKO mice housed at 30 °C (WT mice, n = 4; H1.2AKO mice, n = 6). Scale bar = 50 μm. g qPCR of genes related to lipogenesis, lipid oxidation and thermogenesis in iWAT of WT and H1.2AKO mice housed at 30 °C (WT mice, n = 4; H1.2AKO mice, n = 6; ns not significant; unpaired two-tailed Student’s t test). Data are mean ± S.D. *P < 0.05, **P < 0.01; ns not significant. Source data and exact P values are provided in a Source data file.
