Fig. 4: MOBILE inferred IANs are enriched for canonical pathways and the top associations are literature-verified interactions.

a Gene set enrichment analysis using genes of ligand-dependent associations revealed cell cycle, interferon, and cytokine signaling pathways. Only the top ten significantly enriched pathways are shown for each ligand perturbation (p values <0.05, FDR <0.1, significance tested using default GSEA settings of single-tail null distributions⁸⁰). The bar height corresponds to the normalized enrichment scores (NES). Stars denote pathways enriched specifically for the corresponding ligand condition when only considering the top ten pathways shown. Asterisk denotes conditions with additional EGF treatment. Source data are provided as a Source Data file. b MOBILE finds known and novel associations between proteins, transcripts, and chromosomal region genes. The top ten magnitude-wise associations between RPPA-RNAseq and RNAseq-ATACseq of the FULL IAN are presented. More than half of the associations have prior literature evidence, while some are “Self” associations of the same gene in different assays. Two associations include non-annotated gene products labeled as “Unknown”. At least four of the associations are “Novel” predictions of the MOBILE pipeline. ~ denotes references not showing a direct (causative) relationship between the genes but co-mentioning them as biomarkers of different cancer subtypes or with relationships of candidates’ isoforms. The MOBILE inferred association values are between −1 and 1.