Fig. 4: The lipidomics profile of corona lipids.

a The summary of natural lipid species intensity identified within individual plasm. The mean intensity of each group was summarized from identified corona lipids from each independent individual-plasmas (n = 8) and the pooled lean/obese plasma (n = 1). For box and whisker plots, each data point represents an individual LNPcor averaged from duplicate measurements. The box represents the interquartile range (first quartile, median and third quartile). P value is obtained by two-tailed Mann–Whitney test. Source data are provided as a Source Data file. b The summary of natural lipid species intensity identified within individual-plasma-derived LNPcor. The mean intensity of each group was summarized from identified corona lipids from each independent individual-plasma-derived (n = 8) and the pooled lean/obese plasma-derived LNPcor (n = 1). Uncomplexed LNPs (LNP, dotted lines) and non-specific lipid binding (BG, dotted lines) were also evaluated. For box and whisker plots, each data point represents an individual LNPcor averaged from duplicate measurements. The box represents the interquartile range (first quartile, median and third quartile) with whiskers indicating minima to maxima. P value is obtained by two-tailed Mann–Whitney test. Source data are provided as a Source Data file. c Hierarchical clustering of individual plasma-derived LNPcor using lipidomics fingerprints. Lean and obese plasmas derived LNPcor formed distinct clusters.