Fig. 6: Working model of RlmN as a sensor for oxidative stress. | Nature Communications

Fig. 6: Working model of RlmN as a sensor for oxidative stress.

From: An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis

Fig. 6

Environmental factors as well as certain antibiotics induce reactive oxygen species in Enterococcus faecalis. These lead to the inactivation of RlmN through perturbation of its Fe-S cluster, exerting dual effects on both the ribosome and tRNA. m2A (shown in red) is present in position 37 of selected tRNAs and 23 S rRNA in the peptidyl transferase center of the ribosome. Loss of m2A modifications on the rRNA and tRNA leads to a modified pool of ribosomes and tRNA, which lead to the upregulation of antioxidant response and downregulation of virulence factors for improved survival in the presence of antibiotics.

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