Fig. 7: Higher D2 receptor density and lower D2 affinity in Syt1 cKODA mice. | Nature Communications

Fig. 7: Higher D2 receptor density and lower D2 affinity in Syt1 cKODA mice.

From: Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice

Fig. 7: Higher D2 receptor density and lower D2 affinity in Syt1 cKODA mice.The alternative text for this image may have been generated using AI.

A, B Density of the dopamine D1 receptors (Bmax) (A) and affinity (Kd) for the radioligand [3H]-SCH23390 (B) in Syt1+/+ (n = 4) and Syt1−/− (n = 4) mice. C, D Density of the dopamine D2 receptors (Bmax) (C) and affinity (Kd) for the radioligand [3H]-raclopride (D) in Syt1+/+ (n = 5) and Syt1−/− mice (n = 4). Each binding was analyzed with a series of four serial coronal sections (bregma +1.34 mm to +0.38 mm) and by dividing each section into four quadrants (dorso-lateral, ventrolateral, dorso-medial, and ventro-medial). E Binding potential of D1 and D2 receptors defined as the Bmax/Kd ratio (n = 4 Syt1+/+/4 Syt1−/− for D1 and 5 Syt1+/+/4 Syt1−/− for D2). The data followed a log-normal distribution and two-tailed unpaired t tests were done after the data were converted to a log scale. Error bars represent ± SEM (ns, non-significant; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001). Source data are provided as a Source Data file.

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