Fig. 5: Effect of sulpiride on choice precision. | Nature Communications

Fig. 5: Effect of sulpiride on choice precision.

From: Blocking D2/D3 dopamine receptors in male participants increases volatility of beliefs when learning to trust others

Fig. 5

a Effects of sulpiride on choice uncertainty, estimated in log – space (hence the prime). Dots are participant-level posterior means. The 95% and 50% CrI of effect sizes show a main effect of sulpiride, driven by the A1- group. Boxplots with centre lines as medians, box bounds as 25th and 75th percentiles, and whiskers terminating at maxima/minima (a distance of 1.5 times the IQR away from the 25th and 75th percentiles). Sample sizes in A1+ group, n = 17 placebo, n = 21 sulpiride, and in A1- group n = 21 placebo and n = 17 sulpiride. b Mean proportion of mistake trials (with SEM), with samples sizes as in (a). Means and 95% quantiles of posterior distributions across the four groups are plotted based on a logistic regression model. Corresponding effect sizes below. c, d The choice uncertainty parameter determines the probability weight (c) and therefore the investment distribution (d). Higher values for the placebo group (the A1 group in particular) indicate more extreme investment choices and higher belief inflexibility.

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