Fig. 10: FCGR3A+ cells mainly interact with the endothelium by direct contact but also through secreted mediators. | Nature Communications

Fig. 10: FCGR3A+ cells mainly interact with the endothelium by direct contact but also through secreted mediators.

From: Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection

Fig. 10

a FCGR3A+ cells were reintegrated with endothelial/epithelial cells in a UMAP plot. b UMAP depicting the concomitant expressions of two markers of injury: VCAM1 and HAVCR1. c Dot plot demonstrating select average gene expression values (log scale) and percentage cell types represented in the UMAP plot. d CellChat analysis was performed and the number of incoming and outgoing ligand-receptor interactions is plotted per cell type. e All the significant communications contributing to cell-to-cell signaling inferred by CellChat analysis are depicted: ligand-receptor pairs that significantly contribute to the secreted effectors (left panels), or cell-to-cell direct contact from FCGR3A+ NK or FCGR3A+ monocytes to all other cell types (right panels).

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