Fig. 5: Immune cells are differently compartimentalized in the kidney allograft. | Nature Communications

Fig. 5: Immune cells are differently compartimentalized in the kidney allograft.

From: Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection

Fig. 5

a Radar plots showing the percentage of indicated cell populations as a proportion of the total cell population measured in the glomerular, tubular, vascular, large vascular and interstitial compartments. b Percentage of indicated cells measured in the glomerular vs. non-glomerular area. The mean ± SEM is depicted.The difference between groups was assessed by the two-tailed p value calculated with Mann-Withney test. c Representative case showing a composite fluorescent image of 3 markers (plus autofluorescence, AF) after image processing (top), and the resulting digital reconstruction highlighting the cell types of interest (bottom). The reader should note that FcγRIII+ NK cells and FcγRIII+ nonclassical monocytes infiltrate the glomerulus whereas classical monocytes are located outside of it. d Enrichment of 6 different immune cell types based on their distance to the closest glomerulus. The y-axis represents the percentage of cells (from the total cell population) belonging to a given cell type at a maximum given distance (x-axis) from the closest glomerulus. Different samples from the same Banff classification were pulled to get a single line per category.

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