Fig. 6: FCGR3A+ monocytes are involved in innate myeloid allorecognition. | Nature Communications

Fig. 6: FCGR3A+ monocytes are involved in innate myeloid allorecognition.

From: Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection

Fig. 6

a All myeloid cells identified in the 16 scRNAseq samples were reintegrated in a UMAP plot of 1,168 myeloid cells. b Dot plot demonstrating average gene expression values of canonical lineage markers (log scale) and percentage of myeloid cell types represented in the UMAP plot. c Correlations between inflammation severity (the radius on the polar plot22) and the proportion of each myeloid subset relative to the total number of cells assessed in each biopsy. Spearman’s correlation coefficient represented by a dot with 95% confident interval represented by the error bars. d Pseudotime trajectories for monocytes and macrophages based on Slingshot, showing the common branch of CD14+ monocytes differentiating into either FCGR3A+ monocytes or CD68+, then into CD163+ macrophages. The light grey error band represents the SEM of the gene expression e Profiling of marker genes along these trajectories.

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