Fig. 3: Bioreactor design with constituent components.
From: Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes
a A fully assembled bioreactor prior to implant, with dimensions of 11.5 × 5.7 × 1.8 cm (length × width × height). b Detailed layering of bioreactor components, with one section composed of an SNM, and an acrylic cell insert, sandwiched by two silicone gaskets. A complete bioreactor contains four sections for a total of four SNM, four cell inserts, and eight silicone gaskets. c Blood flow channels are in direct contact with SNM, which are separated from the cell insert by a silicone gasket (cross-sectional view shown). The cell insert is constructed by epoxying a Transwell® membrane to an acrylic piece, which is subsequently seeded with HREC.
