Fig. 5: BFG methylation motifs tile a vast combinatoric space with open panepigenomes over the sequenced isolate set.
a Rarefaction curves of DNA methylation motifs detected in genomes of BFG species in this study and comparison with C. difficile and B. breve species from external studies (denoted with ‘*‘; data9,41). BFG rarefaction curves indicate open panepigenomes over the sequenced isolate set. b–f Heatmaps of detected DNA methylation motifs in Parabacteroides distasonis, B. vulgatus, B. fragilis (sensu stricto), B. ovatus, and B. thetaiotaomicron isolates. Rows indicate individual isolates with corresponding marginal MLST marker gene phylogenies. Columns indicate distinct methylation motifs. The three most prevalent motifs in each set are labeled, and labels are omitted for the rest. Cells are colored when a given motif is present in the corresponding isolate and colors indicate the class of base modification as indicated in the legend. Sequences of all motifs can be found in Supplementary Data 10.
