Fig. 1: TDP-43 translocates from the cytoplasm into the nucleus at the mouse early 2-cell stage and is essential for early embryogenesis. | Nature Communications

Fig. 1: TDP-43 translocates from the cytoplasm into the nucleus at the mouse early 2-cell stage and is essential for early embryogenesis.

From: Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation

Fig. 1: TDP-43 translocates from the cytoplasm into the nucleus at the mouse early 2-cell stage and is essential for early embryogenesis.The alternative text for this image may have been generated using AI.

a Immunostaining of TDP-43 in mouse oocytes and early embryos. GV germinal vesicle oocyte, MII MII oocyte; 1 C 1-cell embryo, 2 C 2-cell embryo, MO morula, BL blastocyst. Scale bar, 10 μm. b Immunostaining of TDP-43 in the 2-cell embryo at different time points. pHCG post HCG injection, h hours. Scale bar, 10 μm. c DIC images of different stage embryos isolated at embryonic day 0.5 (E0.5), E1.5 and E2.5 from the oviducts of control (Tdp43flox/flox) and Tdp43oKO (Tdp43 flox/flox;Zp3-Cre) females mated with normal fertile males. Scale bar, 20 μm. d The average numbers of different stage embryos that were flushed at E0.5, E1.5 and E2.5 from the oviducts of control (n = 16, n = 9, n = 10) and Tdp43oKO (n = 17, n = 13, n = 12) females, the dots represent numbers of the embryos from each female. Error bars, SD (standard deviation).

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