Fig. 6: Treatment with PGG improves pulmonary arterial biomechanics and hemodynamics in a rat model of PH-LHD. | Nature Communications

Fig. 6: Treatment with PGG improves pulmonary arterial biomechanics and hemodynamics in a rat model of PH-LHD.

From: Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

Fig. 6: Treatment with PGG improves pulmonary arterial biomechanics and hemodynamics in a rat model of PH-LHD.The alternative text for this image may have been generated using AI.

a Representative M-mode images acquired by transthoracic echocardiography display dimensions of the LV walls and LV cavity in an AoB-PGG rat at 3 weeks and 5 weeks after surgery. In comparison to 3 weeks, LV shortening was notably reduced at 5 weeks. b M-mode images show PA distensibility in an AoB-PGG rat before (3w) and after (5w) PGG treatment. Yellow arrow points to the clip on the aorta. c Representative images show pulmonary blood flow as detected by pulse-wave and color Doppler echocardiography and the analysis of pulmonary acceleration time (PAT) and pulmonary ejection time (PET) parameters in an AoB-PGG rat before (3w) and after (5w) PGG treatment. d–g Line graphs show longitudinal changes in left ventricular fractional shortening (LVFS), left ventricular ejection fraction (LVEF), pulmonary artery radial strain (PARS), PAT, PAT/PET, and tricuspid annular plane systolic excursion (TAPSE) in AoB-BLN (n = 9) and AoB-PGG (n = 11) animals before (3w) and after (5w) treatment with either vehicle or PGG. Changes between 3 and 5 weeks were detected as follows: LVFS and LVEF (p = 0.0039 for AoB-BLN and p = 0.001 for AoB-PGG), PARS (p = 0.0078 for AoB-BLN and p = 0.0186 for AoB-PGG), PAT (p = 0.0049 for AoB-PGG), PAT/PET (p = 0.0703 for AoB-PGG), and TAPSE (p = 0.0039 for AoB-BLN). Statistics: d–g Two-tailed Wilcoxon matched-pairs signed rank test. Source data are provided as a Source Data file.

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