Fig. 1: Study workflow.
From: Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma
Samples from pre-cancerous, primary and metastatic stages were whole-genome sequenced (WGS) and mutations were called (a). Mutations are timed and categorised into clonal early/late or subclonal (b) before mutational signature analysis (c). Finally, the dynamics of mutational processes are studied in relation to the clonal composition of the samples (d).
