Fig. 2: Scope of the biaryl products with twofold chiral axes.
From: Rhodium-catalyzed enantioselective and diastereodivergent access to diaxially chiral heterocycles
Reaction Conditions A: benzamide (0.1 mmol), alkyne (0.1 mmol), (R)-Rh1 (3 mol%), AgSbF6 (12 mol%), AgOAc (2 equiv), 4-CF3C6H4COOH (1 equiv) at 60 °C in 1,2,3-trichloro-5-(trifluoromethyl)benzene (2 mL), 72 h, isolated yield; at 80 °C; in MeOH (1 mL). Reaction Conditions B: benzamide (0.1 mmol), alkyne (0.12 mmol), (R)-Rh1 (3 mol%), AgOAc (2.0 equiv) and HOPiv (2.0 equiv) in MeOH (2 mL), 40 oC, 48 h, isolated yield. Ag2O (2.0 equiv), 30 °C.
