Fig. 1: Anti-S IgG response to SARS-CoV-2 vaccination relative to delivery in pregnant patients.

a All patients who received at least one dose of SARS-CoV-2 vaccination prior to delivery. Maternal anti-S IgG levels are examined relative to time elapsed since SARS-CoV-2 vaccination dose and delivery (0). The relationship between maternal anti-S IgG levels and time since last vaccination dose relative to delivery was examined by linear regression model for vaccinated and boosted patients; variables contributing to significant differences were determined by mixed ANOVA. Patients are grouped according to vaccination status at time of delivery and history of SARS-CoV-2 infection: Boosted with positive history of infection (BoostVx/Inf); Boosted with no history of infection (BoostVx); Fully vaccinated with positive history of infection (FullVx/Inf); Fully vaccinated with no history infection (FullVx); Partially vaccinated with positive history of infection (PartVx/Inf); Partially vaccinated with no history of infection (PartVx). b–d Maternal anti-S IgG levels in patients with no history of infection stratified by vaccination status at time of delivery: Not vaccinated (NoVx); Partially vaccinated (PartVx); Fully Vaccinated (FullVx); Boosted (BoostVx). Maternal anti-S IgG levels in patients with positive history of SARS-CoV-2 infection stratified by vaccination status at time of delivery: Not vaccinated with positive history of infection (NoVx/Inf); Partially vaccinated with positive history of infection (PartVx/Inf); Fully vaccinated with positive history of infection (FullVx/Inf); Boosted with positive history of infection (BoostVx/Inf). Differences within the no history b and history c groups, as well as differences between groups with the same vaccination status d were examined using two-sided Wilcoxon rank-sum test. Data points are indicated as dots and plotted as boxplots (center line, median; bounds of box, the first and third quartiles; whiskers, 1.5 times interquartile range). Shaded regions indicate 95% confidence intervals for each linear relationship visualized. Source data are provided as a source data file.