Fig. 7: Proposed mechanism of increased RSV B neutralization potency with nirsevimab binding site substitution Q209R. | Nature Communications

Fig. 7: Proposed mechanism of increased RSV B neutralization potency with nirsevimab binding site substitution Q209R.

From: Molecular and phenotypic characteristics of RSV infections in infants during two nirsevimab randomized clinical trials

Fig. 7: Proposed mechanism of increased RSV B neutralization potency with nirsevimab binding site substitution Q209R.The alternative text for this image may have been generated using AI.

Red indicates the electrostatics of the negatively charged pocket on nirsevimab, created by glutamic and aspartic acids (E55 and D101). Green dashed lines indicate polar contacts. F fusion protein, RSV respiratory syncytial virus.

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