Fig. 2: pH-dependence of cKir2.2[G178D] sub-states.
From: Subunit gating resulting from individual protonation events in Kir2 channels
A Representative traces of Kir2.2[G178D] channel activity at different pH. All-point histograms are presented on the right of each trace. B Representative traces of WT Kir2.2 channel activity at different pH. C Distribution of the open probabilities of conductive states of cKir2.2[G178D] at different pH levels. Data are taken from A. D Sub-states amplitudes of cKir2.2[G178D] at −120 mV membrane potential at different pH. E Sub-state amplitudes of cKir2.2[G178D] at pH 7.4 at different membrane potentials. Sub-states could not be reliably resolved at potentials more positive than −60 mV due to a low signal to noise ratio. Data in D and E shown as mean ± s.e.m. (n = 50–1000 transitions within each patch, N = 3–5 patches, for each conductance level).
