Fig. 3: Kinetic model of Kir2.2[G178D] sub-state gating.
From: Subunit gating resulting from individual protonation events in Kir2 channels
A A scheme representing 5 open states (O1 to O5), and 5 brief closed states (C1 to C5). Sequential transitions from state 0 up to state 5 result from single subunit protonation steps. B Experimental data (dots) and model prediction, assuming KH = 2 × 10−7 M−1, KOC = 5 × 10−2.
