Fig. 7: Negative charges in the pore increase the gate diameter, especially of the hydrophobic I177 in the HBC gate. | Nature Communications

Fig. 7: Negative charges in the pore increase the gate diameter, especially of the hydrophobic I177 in the HBC gate.

From: Subunit gating resulting from individual protonation events in Kir2 channels

Fig. 7

A Histograms show the distribution of gate diameters for residues in the HBC gate (I177, M181) and the G-loop gate (M302). Different colors correspond to simulation systems with varying protonation of D173 and G178D. B The location of constricting residues in the pore is shown on two opposing protein chains of the cKir2.2 tetramer.

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