Fig. 1: Crystal structures of the p53-DBD/BCL-2 complex.
From: Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity
a Schematic representation of p53 and BCL-2 constructs. The p53 and BCL-2 constructs are shown as indicated. b Sequences of BCL-2 constructs. The sequence alignment was created using the web services ESPript 3.0. Identical and similar residues are boxed in red and white, respectively. c Schematic representation of the linked BCL-2-p53-DBD constructs. The sequences of glycine-rich linkers are listed as indicated. d Superposition of the three structures of the BCL-2/p53-DBD complex. Structures of 16, 19 and 22 residue-linked complexes are shown as pink, slate and green ribbons, respectively. e Cartoon presentation of the p53-DBD/BCL-2 structure. BCL-2 is shown as gray cartoons with BH1-BH4 colored blue, yellow, purple and red, respectively. p53 is colored green. f Surface presentation of the BCL-2 molecule. g Surface presentation of the p53 molecule by rotating 180° along the y-axis of the view in (f). The black box indicates the interface.
