Fig. 5: Structure-activity relationships of the 2-aryl-4-aminothiazole Tudor domain inhibitors.
From: Pharmacological perturbation of the phase-separating protein SMNDC1
Color-coded chemical structures illustrating structure activity relationships for compound 1. Modifications to the 2-aryl moiety are shown in dark blue, replacements of the thiazole group in orange, linker modifications in green and arylamide analogs in turquoise. Underneath are IC50 values (µM) for SMNDC1 in black and SMN in dark red.
