Fig. 4: Substrate scope of enantioselective borylation of C-P bond. | Nature Communications

Fig. 4: Substrate scope of enantioselective borylation of C-P bond.

From: Diversity-oriented synthesis of P-stereogenic and axially chiral monodentate biaryl phosphines enabled by C-P bond cleavage

Fig. 4

Reaction conditions: 1 (0.10 mmol), B2neop2 (2.0 equiv), [Pd(Allyl)Cl]2 (5 mol%), L5 (22 mol%), CuCl (0.75 equiv), Cs2CO3 (2.0 equiv), p-xylene (1.0 mL) for 12 h, then S8 (5 equiv) or BH3·SMe2 (2 equiv, 10 M in Me2S), unless otherwise stated. Isolated yields were reported. ee values of the major isomers are shown and determined by chiral HPLC analysis. dr values were determined by 1H NMR analysis of the crude reaction mixtures; athe reaction was conducted at 35 °C for 36 h; b0.10 mmol scale.

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