Table 2 Testing the developed ligand library in [3 + 2] annulation of MBH carbonate

From: Diversity-oriented synthesis of P-stereogenic and axially chiral monodentate biaryl phosphines enabled by C-P bond cleavage

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Entry

Ligand

12

  

Yield (%)

e.e. (%)

dr

1

MOP

trace

N.D.

N.D.

2

L7

trace

N.D.

N.D.

3

L8

92

67

>25:1

4

L9

40

84

>25:1

5

L10

98

83

>25:1

6

L11

93

94

>25:1

  1. Reaction conditions: 10 (0.1 mmol), 11 (0.12 mmol), 20 mol% L*, 1.0 mL toluene, room temperature, 22 h, under argon. Yields are those of isolated products.
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