Fig. 1: 3D spatial transcriptional atlas for mouse organogenesis at E13.5.
From: Three-dimensional molecular architecture of mouse organogenesis
a Schematic overview of experimental design and analysis workflow for the spatial transcriptome of mouse organogenesis at E13.5. b UMAP projection and clustering of the spatial transcriptome from all sections and spots, colored by spatial domains (Top) and sections (Bottom). c The spatial distribution of 19 UMAP clusters in (b) across all embryo tissue sections, annotated according to anatomical structures and molecular features in (d). d The heatmap showing the expression pattern of the top five representative marker genes for each spatial domain. Examples of marker genes are listed together with the enriched Gene Ontology (GO) terms for selected spatial domains. e UMAP projection and spatial expression distribution of selected marker genes, Myog, Gal, and Ptgds across all the ten embryo sections. S section, D domain.
