Fig. 8: ARID1A regulates cardiomyocyte proliferation through interaction with YAP. | Nature Communications

Fig. 8: ARID1A regulates cardiomyocyte proliferation through interaction with YAP.

From: Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation

Fig. 8

In neonatal cardiomyocytes (left), the Hippo pathway is inactive, and YAP translocates to the nucleus where it teams up with TEAD factors to drive a pro-proliferative gene program. Proliferation genes are marked by open chromatin and H3K27Ac histone marks. As cardiomyocytes switch towards maturation, ARID1A binds YAP, inhibiting its transcriptional activity. Proliferation gene program is stably silenced by decreased H3K27Ac levels and transcriptionally inactive heterochromatin. During cardiomyocyte maturation, ARID1A is required for inducing activation of cardiac contractility and metabolism genes, driven by MEF2 and ESRR transcription factors. Created with BioRender.com.

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