Fig. 5: Intracellular lateral gate in distinct conformations. | Nature Communications

Fig. 5: Intracellular lateral gate in distinct conformations.

From: Architecture and autoinhibitory mechanism of the plasma membrane Na+/H+ antiporter SOS1 in Arabidopsis

Fig. 5: Intracellular lateral gate in distinct conformations.The alternative text for this image may have been generated using AI.

a–c Conformational transition of SOS1 and NHE1-CHP1 among the inward-facing state (a), the occluded state (b), and the outward-facing state (c), viewed in the membrane plane. The core domain is shown as surfaces and colored according to electrostatic potential. TM5, TM6, TM10, and TM12 are shown as cartoons. TM5 and TM12 are colored in rainbow. Asp172SOS1 and Asp201SOS1 (Asp238NHE1 and Asp267NHE1) are critical for ion binding and are labeled in red. Conformational change of TM5b is highlighted by showing the Cα of N-terminal (cyan, Pro173SOS1 and Pro239NHE1) and Cα of C-terminal (green, Lys181SOS1 and Glu247NHE1) residues in α-helical form as spheres. The centers of mass (COMs) of the core domain and dimerization domain are calculated using transmembrane helices and are shown as dots. COMC, core domain, black; COMD, dimerization domain, gray.

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