Fig. 5: FAP106 is required for parasite motility and assembly of conserved and lineage-specific MIPs at the inner junction. | Nature Communications

Fig. 5: FAP106 is required for parasite motility and assembly of conserved and lineage-specific MIPs at the inner junction.

From: FAP106 is an interaction hub for assembling microtubule inner proteins at the cilium inner junction

Fig. 5: FAP106 is required for parasite motility and assembly of conserved and lineage-specific MIPs at the inner junction.The alternative text for this image may have been generated using AI.

Normal parasite motility relies on FAP106 as a critical interaction hub for assembly of MIPs at the inner junction (IJ). Cross-sectional and longitudinal views of the DMT are illustrated. Conserved IJ MIPs PACRG-A, FAP20 and FAP52 assemble independently of FAP106, however PACRG-B does not stably assemble into the IJ filament without FAP106. The B-tubule remains intact and connected to the A-tubule at the IJ, despite loss of multiple IJ MIPs. FAP106 is also critical for assembly of the conserved MIP, FAP45, and a FAP210-like protein (modeled as filaments based on published structures13,15,21), as well as several previously unknown lineage-specific MIPs.

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