Table 2 Proteins significantly reduced in FAP106 KD flagellum skeletons by TMT proteomics

From: FAP106 is an interaction hub for assembling microtubule inner proteins at the cilium inner junction

Protein

Gene ID

aFold reduction

bAdjusted p value

Protein localization

Function

FAP106

Tb927.11.4880

24.02

0.0011

Flagellum

B-tubule MIP

FAP45

Tb927.8.4580

3.95

0.0035

Flagellum

B-tubule MIP

PACRG-B

Tb927.9.9940

2.77

0.0576

Flagellum

IJ filament

MC5

Tb927.11.4920

13.74

0.0003

Flagellum

MIP candidatec

MC3

Tb927.10.7120

3.44

0.0044

Flagellum

MIP candidatec

MC8

Tb927.11.2770

2.81

0.0111

Flagellum

MIP candidatec

MC15

Tb927.3.3200

1.95

0.0177

Flagellum

MIP candidatec

RPC19

Tb927.11.8890

2.99

0.0055

Nucleus

RNA polymerase

  1. aSource data are provided as a Source Data file.
  2. bModerated two-sided t-test with Benjamini–Hochberg adjustment for multiple comparisons.
  3. cMIP candidates were identified by independent APEX2-based proximity proteomics using known B-tubule MIPs FAP45 and FAP52 as bait (see Supplementary Data 2).
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