Table 4 Quantitative LRC analyses of time to first disease in LLS en SEDD

From: Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles

 

N

Events (prop)

HR (95% CI)

P-value

A: LLS data

 Age-related diseases

1312

533 (0.41)

0.95 (0.91–0.99)

3.06 × 10−2

 Metabolic diseases

1312

396 (0.30)

0.93 (0.88–0.98)

1.37 × 10−2

 Malignancies

1312

186 (0.14)

0.97 (0.91-1.04)

4.98 × 10−1

B: SEDD data

 Age-related diseases

2497

1,190 (0.48)

0.94 (0.89–0.98)

1.22 × 10−3

 Metabolic diseases

2497

706 (0.28)

0.91 (0.87–0.96)

4.84 × 10−3

 Malignancies

2497

671 (0.27)

0.95 (0.90–0.99)

4.43 × 10−2

 Death

2497

694 (0.28)

0.92 (0.87–0.97)

1.72 × 10−3

  1. Table shows the time from inclusion to first disease. N is the group size. Events are the events of the specific diseases, for example, age-related diseases, and prop. indicates the proportion from the size of a specific disease group. for example, 533 (41%) out of the 1312 persons had an age-related disease. HR represents the estimated effect size. Statistical testing was performed using Wald tests for the conditional log-hazard ratio estimated with a Cox-type frailty regression model. The analyses are adjusted for sex, different ages of study entry (left truncation) and right censoring. Only persons without any disease at inclusion are studied.
  2. sd standard deviation, HR hazard ratio.
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