Table 4 Absolute values and changes in HOMA-IR, fasting blood glucose and insulin in each treatment group
From: Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes
HOMA-IR (units), Median and IQR (n) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Baseline | 6 months | Δ6 mo. | 12 months | Δ12 mo. | 18 months | Δ18 mo. | 24 months | Δ24 mo. | |
Placebo | 2.2 | 2.6 | −0.2 | 2.9 | +0.8 | 2.0 | −0.2 | 2.0 | −0.3 |
2.0–2.6 (n = 12) | 2.1–3.1 (n = 12) | −0.6 to 1.0 | 1.8–4.2 (n = 9) | −0.7 to 2.3 | 1.6–3.8 (n = 8) | −0.9 to 2.3 | 1.4–2.7 (n = 6) | −0.8 to 0.6 | |
L3-20 | 3.0 | 2.3 | −0.6 | 1.8a | −1.1b | 1.6 | −1.5 | 2.1a | −0.8 |
2.3–3.5 (n = 13) | 1.5–3.2 (n = 11) | 1.9 to −0.1 | 1.7–2.5 (n = 11) | −1.5 to −0.5 | 0.9–3.0 (n = 8) | −1.8 to −0.1 | 1.5–2.3 (n = 7) | −1.3 to −0.4 | |
L3-40 | 2.4 | 2.1 | −0.5 | 2.4 | −0.4 | 2.5 | −0.3 | 1.5 | −0.5 |
2.1–3.0 (n = 11) | 1.8–2.6 (n = 11) | −1.2 to 0.2 | 1.7–3.2 (n = 10) | −1.4 to 0.9 | 1.9–3.1 (n = 8) | −0.4 to 0.4 | 1.0–4.8 (n = 9) | −1.2 to 1.1 | |
Fasting blood glucose (mmol/L), Median and IQR (n) | |||||||||
Placebo | 4.8 | 5.0 | 0.0 | 4.8 | +0.3 | 4.6 | −0.1 | 4.0 | −0.8 |
4.5–5.1 (n = 12) | 4.0–5.3 (n = 12) | −0.5 to 0.5 | 4.4–5.4 (n = 9) | −0.4 to 0.8 | 4.2–5.3 (n = 8) | −0.7 to 0.6 | 3.1–5.1 (n = 6) | −1.9 to 0.6 | |
L3-20 | 5.2 | 4.5a | −0.7 | 4.2 | −0.9 | 4.5 | −0.5 | 4.7 | −0.6 |
4.7–5.6 (n = 13) | 4.0–5.1 (n = 11) | −1.0 to −0.3 | 3.6–5.6 (n = 11) | −1.1 to 0.6 | 4.2–4.7 (n = 8) | −1.0 to 0.1 | 3.9–4.8 (n = 7) | −1.2 to −0.4 | |
L3-40 | 5.3 | 4.3a | −0.7b | 4.1a | −1.0b | 4.5a | −0.4 | 4.3a | −0.6 |
4.9–5.4 (n = 11) | 4.0–5.3 (n = 11) | −1.0 to −0.6 | 3.7–4.9 (n = 10) | −1.4 to −0.7 | 4.1–5.1 (n = 8) | −1.2 to 0.0 | 4.0–4.9 (n = 9) | −1.1 to -0.4 | |
Fasting blood insulin (mmol/L), Median and IQR (n) | |||||||||
Placebo | 11 | 12 | +1 | 12 | +2 | 11 | 0 | 11 | +1 |
9–12 (n = 12) | 10–15 (n = 12) | −2 to 4 | 8–19 (n = 9) | −3 to 10 | 8–6 (n = 8) | −3 to 8 | 10–14 (n = 6) | −1 to 2 | |
L3-20 | 13 | 10 | −2 | 10a | −4b | 9 | −5 | 10 | −3 |
12–16 (n = 13) | 7–14 (n = 11) | −7 to 1 | 9–14 (n = 11) | −5 to −3 | 5–14 (n = 8) | −7 to −1 | 7–12 (n = 7) | −4 to 1 | |
L3-40 | 10 | 10 | −1 | 12 | +1 | 12 | +2 | 8 | −1 |
9–13 (n = 11) | 9–15 (n = 11) | −3 to 2 | 9–18 (n = 10) | −4 to 6 | 10–17 (n = 8) | −1 to 3 | 6–22 (n = 9) | −5 to 8 | |
