Fig. 8: A circuit model for locomotion to regulate olfactory learning through proprioception.
From: Locomotion modulates olfactory learning through proprioception in C. elegans
Locomotion activates A- and B-MNs by stimulating their mechanoreceptors, which are formed by ASIC-1 and DEL-1 in VA and VB but unidentified in DA and DB. A- and B-MNs then activate the locomotion interneurons AVA and AVB, respectively, through antidromic-rectifying gap junctions. The gap junctions between AVB and B-MNs are formed by UNC-7 and INX-19 in AVB and UNC-9 in B-MNs, while those between AVA and A-MNs by UNC-7 in AVA and UNC-9 in A-MNs. RIM, AVB, and AVA interact through inhibitory tyraminergic synapses from RIM to AVB, and inhibitory cholinergic synapses from AVB to AVA, with LGC-55 and ACC-2 being the postsynaptic receptors in AVB and AVA, respectively. Gap junctions and excitatory chemical synapses also exist between RIM and AVA.
