Fig. 6: The effect of BLT1 on PfMSP1 development. | Nature Communications

Fig. 6: The effect of BLT1 on PfMSP1 development.

From: Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures

Fig. 6: The effect of BLT1 on PfMSP1 development.The alternative text for this image may have been generated using AI.

The percentage of HuHep Schizonts positive for PfMSP1 expression for NF175 (A), NF135 (B), and NF54 (C). A total of two biological experiments were performed (n = 2), each with two technical replicates: at least 100 schizonts were measured from each technical replicate except for NF54 due to low numbers of schizonts surviving. Each bar represents the average and error bars (SD) of two technical replicates (A–C) from two biological experiments (n = 2). Confocal images showing DMSO and BLT1 treated schizonts stained for PfMSP1 and PfHSP70 for NF175 (D), NF135 (E), and NF54 (F) in HuHeps. Scale bar is 25 microns. These images are a representative from two independent experiments. Sidak’s multiple comparison test (two sided) is used to compare the DMSO and BLT1 conditions for each parasite strain (A–C): the p values for the significant parameters are annotated (*p < 0.05, **p < 0.01, ***p < 0.001). For A, p value is 0.0488; B (left to right), p values are 0.0054 and 0.0012.

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