Fig. 2: Chromosome X architecture captures intra- and inter-patient diversity.
From: Copy number architectures define treatment-mediated selection of lethal prostate cancer clones
a–j Skyline plots (drawn using Graphpad prism) showing the proportion of samples in each patient with copy number gains (≥2 copies, along y-axis) at individual bins (500 kb wide) across chromosome X (along x-axis) (Supplementary Data 6). Number of metastatic samples per patient (n) is provided for each panel. Vertical dotted lines denote position of AR gene and associated enhancer region. e Inset used to show focal gain in AR, not evident at low resolution in the skyline plot. Orange squares depict mean copy number for contributing segment(s) and black dots represent copy number of each bin. Number of metastatic samples used per patient - CA35: n = 5, CA79: n = 12, PEA172: n = 25, CA36: n = 11, CA43: n = 10, CA63: n = 36, CA27: n = 15, CA34: n = 10, CA76: n = 18, CA83: n = 25.
