Fig. 5: CAND1 restrains the formation of Cullin1, FBXO42 and ACAA2 complexes. | Nature Communications

Fig. 5: CAND1 restrains the formation of Cullin1, FBXO42 and ACAA2 complexes.

From: Cullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2

Fig. 5: CAND1 restrains the formation of Cullin1, FBXO42 and ACAA2 complexes.The alternative text for this image may have been generated using AI.

a Livers of WT and cKO mice after 16 weeks of NC or HFD-feeding immunoprecipitated with anti-ACAA2/Cullin1/FBXO42 antibodies and then immunoblotted with antibodies specific for ACAA2/FBXO42/Cullin1, and quantification of the relative ACAA2/FBXO42/Cullin1 level (n = 3). b Livers of WT and cKI mice after 16 weeks of NC or HFD-feeding immunoprecipitated with anti-ACAA2/Cullin1/FBXO42 antibodies and then immunoblotted with antibodies specific for ACAA2/FBXO42/Cullin1, and quantification of the relative ACAA2/FBXO42/Cullin1 level (n = 3). p values obtained via one-way ANOVA with Tukey’s multiple comparisons test. The data were shown as means ± SD of independent biological replicates. Source data are provided as a Source data file.

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