Fig. 1: Synthetic approaches to bioactive thioamides.
From: Nitroalkanes as thioacyl equivalents to access thioamides and thiopeptides
a Examples and importance of thioamide moieties in bioactive compounds. b and c Current strategies and common limitations for thioamide synthesis. b An O → S exchange approach requires the use of excess sulfur reagents. c A multi-step sulfur incorporation approach to making thioacylating substrates to generate thioamides. d This work: A direct and general method to thioacylate amines with nitroalkanes using elemental sulfur.
