Fig. 3: TRPV6THCV Pore.
a Pore-forming domain in TRPV6THCV with the residues contributing to pore lining in the THCV-bound (TRPV6THCV), ruthenium red-bound (TRPV6RR), econazole-bound (TRPV6Eco), and apo-state (TRPV6Open) structures shown as sticks. Only two of four subunits are shown, with the front and back subunits omitted for clarity. The pore profile is shown as a space-filling model (gray). The region that undergoes α-to-π transition in S6 is highlighted in pink. b Pore radius for TRPV6THCV (green), TRPV6RR (blue, PDB ID: 7S8B), TRPV6Eco (cyan, PDB ID: 7S8C) and TRPV6Open (orange, PDB ID: 7S89) calculated using HOLE. The vertical dashed line denotes the radius of a water molecule, 1.4 Å.
