Fig. 4: Substrate scope of 1,3-enynes 2.
From: Copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of 1,3-enynes and azomethine ylides
Reaction conditions: 1a (0.26 mmol), 2 (0.20 mmol). Isolated yields were reported. Ee and dr were determined by chiral-stationary-phase HPLC analysis. a10 mol% catalyst and 40 mol% Cs2CO3 were used. 1.0 M. 48 h. btrans-1,3-enyne used. ccis-1,3-enyne used.
