Fig. 5: Preliminary investigation of the catalytic asymmetric construction of tetrasubstituted carbon.
From: Copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of 1,3-enynes and azomethine ylides
Reaction conditions: 4/5 (0.26 mmol), 2 (0.20 mmol). Isolated yields were reported. Ee and dr were determined by chiral-stationary-phase HPLC analysis. a60 °C.
