Table 1 Comparison of Drop-BS with other single-cell bisulfite sequencing techniques
From: Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes
Mapping efficiency | Throughput by one operator | Unique reads per cell (sequencing depth per cell) | CpGs covered per cell | Bisulfite conversion rate | |
|---|---|---|---|---|---|
Drop-BS | 65% | 10,000 cells in 2 days | 41,013 (231,382) | 24,230 | 99% |
snmC-seq | 55% | 384 cells per wellplate | 1.7 M (6.9 M) | 1.7 M | 99% |
sciMET | 60% | 500–700 cells per experiment | 186,710 (755,529) | 162,045 | 99% |
sciMET v2 | 69% | 1000 cells per experiment | 3.1 M (4.9 M) | 2.2 M | 99% |
scBS-seq | 20% | 44 cells sequenced in the paper | 3.0 M (19.4 M) | 3.7 M | 98.5% |
