Fig. 6: Summary of proposed EEA1 ‘trigger-and-convert’ mechanism of maturation. | Nature Communications

Fig. 6: Summary of proposed EEA1 ‘trigger-and-convert’ mechanism of maturation.

From: Deterministic early endosomal maturations emerge from a stochastic trigger-and-convert mechanism

Fig. 6: Summary of proposed EEA1 ‘trigger-and-convert’ mechanism of maturation.The alternative text for this image may have been generated using AI.

Very early endosomes formed at the cell periphery (endosome 1) have PI(3,4)P2 (orange)-containing membranes and APPL1 (cyan) bound to Rab5 (grey). These vesicles collide with mature EEA1 vesicles (endosome 0), seeding N-terminally bound EEA1 and triggering the conversion process. This enables the production of PI(3)P (red) and the binding of C-terminal EEA1. These vesicles can trigger conversions on nascent APPL1 vesicles (endosome 2) and participate in canonical endosomal tethering and fusion processes (bottom endosomes).

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