Fig. 1: DNA/MVA-ID/protein vaccine shows protection against acquisition of infection on intravaginal low dose SHIV BG505 challenge.

a Schematic representation of vaccine groups and the immunization schedule. Arrows were color-coded to represent the immunogen/virus challenge and denote the time in weeks of their administration. b Kaplan–Meier survival curves representing the fraction of uninfected animals following each challenge on the y-axis (n = 10 in each vaccinated group and n = 15 in the control (adjuvant-only) group). c–e Plasma viral load in infected animals post-infection. The week in which viremia was first detected was considered as Wk1. c Longitudinal viral load profile representing the geomean of all infected animals in each group. Asterisks denoting statistical significance measured by Mann–Whitney rank-sum test (two-tailed) and were color-coded for each group (red: MVA-ID; blue: MVA-IM), compared to control group, and black: MVA-ID compared to MVA-IM group; second week: red/blue: ****p < 0.0001; third week: blue: ***p = 0.0001, black: **p = 0.008; fifth week: red: *p = 0.02, blue: ***p = 0.0005; 11th week: blue: *p = 0.018. d Area under the curve of longitudinal viral load in infected animals, compared between the groups; box in the plot extends from the 25th percentile to the 75th percentile of the dataset and the line inside the box denotes the median. The whiskers descend to the dataset’s minimum values and ascend to the maximum values; Asterisks in viral load data, denote statistically significant differences between the groups at the given time point, measured by Mann–Whitney rank-sum test (two-tailed) (****p < 0.0001, ***p = 0.0006, *p = 0.035). e Longitudinal viral load profile of each infected animal. Infected animals in control group: n = 14, MVA-ID group: n = 6, MVA-IM group: n = 7. Source data are provided as a Source Data file.