Fig. 6: Change in intra-helical distances between active and inactive states, Δd = dactive − dinactive, for AT1 receptor in SOPC with no agonist bound and 10 mN/m tension (light blue), in SOPC:SOPE (gray), in POPC (green), in SOPC with S1I8 bound (red), and in SOPC with AngII bound (purple). | Nature Communications

Fig. 6: Change in intra-helical distances between active and inactive states, Δd = dactive − dinactive, for AT1 receptor in SOPC with no agonist bound and 10 mN/m tension (light blue), in SOPC:SOPE (gray), in POPC (green), in SOPC with S1I8 bound (red), and in SOPC with AngII bound (purple).

From: Membrane mediated mechanical stimuli produces distinct active-like states in the AT1 receptor

Fig. 6

Values shown as box and whiskers plots including median, quartiles, and extrema of the combined data from the two replicas over the last 500 ns of the 2 μs simulations (n = 2 independent simulations, 200,000 time points analyzed). The 4YAY crystal structure of the AT1 receptor with a selective antagonist bound was used as the reference inactive structure.

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